Previous reports have shown that EGFR translocation to the nucleus is associated with cell proliferation. Here we investigated mechanisms of acquired resistance to cetuximab using a model derived ...

EGFR as a molecular target has yet to be individualized for ... AKT activation is initiated by translocation to the plasma membrane. AKT phosphorylation is carried out by 3-phosphoinositide-dependent ...

A schematic diagram showing the significant contribution of SCoV2-induced altered mitochondrial dynamics and mitochondrial EGFR translocation in sustaining viral propagation. First, SCOV2 RNA and ...

That means they’re the main cause of your cancer growth and cell division. Epidermal growth factor receptor (EGFR) mutation is one biomarker doctors look for during testing. EGFR is a protein on ...

If you have EGFR-positive lung cancer, you have some choices to make about treatment options. Especially if your cancer is advanced. Your doctors can help you choose from a list of approved drugs ...

They found both previously known and novel mutations significantly linked to EGFR activation and drug response, demonstrating the method's precision and revealing new pathways affecting tumor ...

Please provide your email address to receive an email when new articles are posted on . Newer eGFR calculations that do not consider race show a link between kidney function and dementia.

Declines in eGFR after transition to sacubitril/valsartan for HF are mild and temporary. Image: Adobe Stock “Moreover, although some of these drugs have demonstrated renal protective effects ...

A novel topical formulation of a BRAF inhibitor significantly reduced acneiform rash associated with anti–epidermal growth factor receptor (EGFR) therapies in patients with colorectal cancer ...

The Rybrevant-Lazcluze combo significantly reduced the risk of death by 25% versus Tagrisso in patients with newly diagnosed advanced EGFR-mutated NSCLC, according to data from the phase 3 ...

Initial change in eGFR after tolvaptan administration independently predicted the annual rate of eGFR decline in patients with ADPKD. Initial declines in estimated glomerular filtration rate (eGFR ...