The epidermal growth factor receptor (EGFR) is expressed in ovarian cancer, but agents targeting this pathway have shown little effect as single agents. This may be due to the presence of ...

In a recent study, researchers have uncovered the biological trigger behind the dangerous immune-related adverse events (irAEs) that occur when the ...

In a recent study published in the journal Nature Biotechnology ... linked to EGFR activation and drug response, demonstrating the method's precision and revealing new pathways affecting tumor ...

the pathway of epidermal growth factor receptors (EGFR) - in the differentiation of the planarian digestive lineage. EGFR pathway, evolutionarily preserved, has a fundamental role when regulating ...

They report their findings in PLOS Genetics. "The results of our research first and foremost solve a long-standing question about the nature of EGFR signaling and how it drives development," said ...

Le et al: These data aligned with previous randomized clinical trials combining VEGF pathway inhibitors with first-generation EGFR TKIs. In the [2019] RELAY study, the addition of ramucirumab to ...

One pathway that is affected by cancer is the epidermal growth factor receptor (EGFR) pathway. As this signaling chain is usually overactivated in cancer, treatment options often include EGFR ...

By activating the EGF/EGFR signaling pathway and downstream cascades, such as Src/PI3K/Akt/mTOR, it may be possible to enhance the motility and proliferative capacity of oral keratinocytes during ...

The organoid with the mutation is greener than the one without the mutation, meaning that it has higher activity of the EGFR signaling pathway. The Organoid group at the Hubrecht Institute have ...