The epidermal growth factor receptor (EGFR) is expressed in ovarian cancer, but agents targeting this pathway have shown little effect as single agents. This may be due to the presence of ...

A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR ...

Radiation therapy can promote the epidermal growth factor receptor (EGFR) ligand amphiregulin, which increases growth of ...

Research reveals why EGFR-targeted cancer therapies often face resistance, leading to ongoing studies on combination treatments.

Please use one of the following formats to cite this article in your essay, paper or report: APA. Chaphalkar, Sushama R.. (2024, November 14). Scientists map cancer mutations in EGFR gene ...

For patients with acute MI at increased risk for HF, empagliflozin showed cardiorenal benefits and was safe to initiate early ...

EGFR pathway: revealing enigmas about cell differentiation. Since the discovery of the epidermal growth factors (EGF) in 1962, isolated by Stanley Cohen (Nobel Prize in Medicine 1986), ...

Resistance to EGFR inhibition might also be mediated by activation of alternative and/or downstream pathways that bypass EGFR and activate extracellular signal-regulated kinase 1/2 (ERK1/2). Yonesaka ...

Molecular alterations in additional nodes of the EGFR pathway also seem to confer primary resistance to targeted therapies. Among them, PIK3CA exon 20 mutations and PTEN alterations, which frequently ...

Nakagawa et al: The stratified OS HR was 0.98 (95% CI 0.78-1.24, P=0.864), median OS (mOS) was 51.1 months for RAM-ERL and 46.0 months for placebo-ERL.For the subgroups of patients by EGFR ...

The article, “The EGF/EGFR axis and its downstream signaling pathways regulate the motility and proliferation of cultured oral keratinocytes” was published on 27 May 2023 in FEBS Open Bio ...