Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent ...

In a recent study, researchers have uncovered the biological trigger behind the dangerous immune-related adverse events (irAEs) that occur when the ...

One pathway that is affected by cancer is the epidermal growth factor receptor (EGFR) pathway. As this signaling chain is usually overactivated in cancer, treatment options often include EGFR ...

Le et al: These data aligned with previous randomized clinical trials combining VEGF pathway inhibitors with first-generation EGFR TKIs. In the [2019] RELAY study, the addition of ramucirumab to ...

Exosomal RNAs, including miRNA, mRNA, and lncRNA, are secreted by tumor cells and play a pivotal role in cancer progression by modulating key signaling pathways such as NF-κB, EGFR, and PI3K/AKT ...

the targeted blockade of the EGFR signaling pathway - even in the presence of a KRAS mutation. This could make KRAS-mutated colon cancer more treatable than previously thought. Our results show ...

By activating the EGF/EGFR signaling pathway and downstream cascades, such as Src/PI3K/Akt/mTOR, it may be possible to enhance the motility and proliferative capacity of oral keratinocytes during ...

“Early on in my career, we identified this EGFR pathway as one therapeutic opportunity to improve cancer outcomes,” says Ramalingam. In the recent study, Ramalingam found that people with ...

One pathway that is affected by cancer is the epidermal growth factor receptor (EGFR) pathway. As this signaling chain is usually overactivated in cancer, treatment options often include EGFR ...