In a recent study, researchers have uncovered the biological trigger behind the dangerous immune-related adverse events ...

TCTP-induced phosphorylation of EGFR stimulates the differential multi-signaling pathway To dissect EGFR ... H-Ras-transformed MCF10A cells with NADPH oxidase-specific inhibitor (DPI) and/or ...

The researchers believe the EGFR pain pathway they found in mice and fruit flies is relevant to humans because of genetic results also reported in the paper on human cohorts with chronic facial ...

One pathway that is affected by cancer is the epidermal growth factor receptor (EGFR) pathway. As this signaling chain is usually overactivated in cancer, treatment options often include EGFR ...

Using tracer compounds, scientists have been able to track the cellular production of NADPH, a key coenzyme for making fat, through a pathway that has never been measured directly before.

In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer ...

They examined additional members of the EGFR signaling pathway, predicting that KRAS wild-type tumors would fail to respond to cetuximab if signaling was driven by other mechanisms of constitutive ...

Background: EGFR-driven NSCLCs are dependent on the EGFR pathway for proliferation which EGFR TKIs potently block. Progression occurs when resistance to erlotinib develops—through the emergence of ...

Patil’s research is looking at how that resistance occurs and how two other pathways, known as the EGFR and MET signaling pathways, play a role. “What is happening is that the cancer cells are ...

One pathway that is affected by cancer is the epidermal growth factor receptor (EGFR) pathway. As this signaling chain is usually overactivated in cancer, treatment options often include EGFR ...