Using tracer compounds, scientists have been able to track the cellular production of NADPH, a key coenzyme for making fat, through a pathway that has never been measured directly before.

TGF-α is involved in the induction of cellular proliferation, migration, invasion and apoptosis by activating the EGF receptor (EGFR) signaling pathway. miRNAs are a family of small ncRNAs that ...

The researchers believe the EGFR pain pathway they found in mice and fruit flies is relevant to humans because of genetic results also reported in the paper on human cohorts with chronic facial ...

Patil’s research is looking at how that resistance occurs and how two other pathways, known as the EGFR and MET signaling pathways, play a role. “What is happening is that the cancer cells are ...

They added that the EGFR pathway is integral to epidermal keratinocytes. Due to this association, it may be a reasonable hypothesis that EGFR inhibitors interfere not only with the epidermal ...

We have particularly deep expertise in targeting the transforming growth factor-beta (TGF-β) and epidermal growth factor receptor (EGFR) pathways. For both of these pathways, there is a ...

Background: EGFR-driven NSCLCs are dependent on the EGFR pathway for proliferation which EGFR TKIs potently block. Progression occurs when resistance to erlotinib develops—through the emergence of ...

One pathway that is affected by cancer is the epidermal growth factor receptor (EGFR) pathway. As this signaling chain is usually overactivated in cancer, treatment options often include EGFR ...

“Early on in my career, we identified this EGFR pathway as one therapeutic opportunity to improve cancer outcomes,” says Ramalingam. In the recent study, Ramalingam found that people with ...

The researchers believe the EGFR pain pathway they found in mice and fruit flies is relevant to humans because of genetic results also reported in the paper on human cohorts with chronic facial ...