“Our data provide evidence that BUB1 protein and its kinase activity may regulate EGFR activation, endocytosis, degradation, and downstream signaling without affecting other members of the ...

EGFR as a molecular target has yet to be individualized ... Fig 2. Overview of Class 1 PI3K signaling and downstream effects. PI3K-AKT signaling plays a pivotal role in normal and cancer physiology ...

but that abrogation of downstream signaling requires a higher dose. 28 Thus, in patients with gliomas, in whom biologic dependence on EGFR signaling is identified by the presence of gene ...

CS2011 is a bispecific antibody with high binding affinity to both EGFR and HER3. It effectively blocks downstream signaling of both targets, thereby inhibiting tumor growth on EGFR/HER3 positive ...

KRAS mutations are among the most common genetic alterations in cancer and are considered particularly difficult to treat.

Creative Biolabs recently updated its antibody chip platform, expanding product arrays for phosphorylation signaling and ...

As explained by Patel, systemic EGFR-targeted therapies block EGFR activity and downstream signaling in multiple organs -- including the skin -- which can lead to subsequent dysregulation of skin ...

Cancer cells may acquire the capacity for autonomous and dysregulated proliferation through the uncontrolled production of specific molecules that promote cell growth (growth factors) or through ...