Finally, the rate of illegitimate integration and vector expression was assessed for IN, LTR att and PPT mutations alone or in combination. To determine whether the mutants were infectious ...

It might be possible to modify vector components and cell growth conditions to channel PICs into desired chromosomal locations. The ability to target retroviral integration will significantly ...

The risk of second tumors after chimeric antigen receptor (CAR) T-cell therapy, especially the risk of T-cell neoplasms related to viral vector integration, is an emerging concern. A total of 724 ...

1 The researchers analyzed more than 280,000 vector integration sites (VIS) from 10 patients with X-linked severe combined immunodeficiency (SCID-X1), also known colloquially as “bubble boy ...