several NCI- sponsored trials are testing drugs against signal transduction targets. One such molecule is genistein, a soy bean natural product that is a known protein-tyrosine kinase inhibitor ...

Zhong, Z.L. Wen, J.E. Darnell, Jr., "STAT3-a STAT family member activated by tyrosine phosphorylation in response ... are two among a host of highly cited reports on the subject of signal transduction ...

Signal transduction by cell adhesion receptors ... Integrin cytoplasmic tyrosine motif is required for outside-in aIIbb3 signalling and platelet function. Nature 401, 808–811 (1999).

As such, kinases are key signal transduction molecules relevant in ... content peptide microarray containing phosphorylatable tyrosine (PTK chip) or serine/threonine (STK chip) residues within kinase ...

Research in our laboratory aims to characterize the molecular mechanisms underlying cell-to-cell interactions and signal transduction across the ... Tie2 and Eph Receptor Tyrosine Kinase Activation ...

Cellular and molecular biology, protein tyrosine phosphorylation, pseudophosphatase roles in signal transduction, protein ... functional characteristics of the pseudophosphatase map kinase ...

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause the ... including transmembrane tyrosine kinases and steroid receptors. The ...