Tyrosine kinase inhibitors (TKIs) are used for the targeted treatment of cancer. TKIs produce a range of serious adverse events requiring careful patient management to maintain treatment benefit ...

Tyrosine kinase inhibitors (TKIs), such as sunitinib and sorafenib, are cancer treatments linked to hypothyroidism in up to ...

suggest that patients with a type of blood cancer called chronic lymphocytic leukemia (CLL) who are being treated with Bruton ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine ... a challenge for cancer therapy. Even as inhibitors that target ...

U.S. FDA Grants Full Approval of VITRAKVI® (larotrectinib) for Adult and Pediatric Patients with NTRK Gene Fusion-Positive ...

such as lung cancer, in which the mutation of the epidermal growth factor receptor (EGFR) kinase imparts resistance to erlotinib. Although we predict that protein tyrosine kinase inhibitors such ...

This article reviews previous experiences and current and future development strategies of sorafenib in breast cancer. Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors ...

Ipsen and Exelixis could expand the use of blockbuster oncology drug Cabometyx into prostate cancer ... suggest that the combination of tyrosine kinase inhibitor (TKI) Cabometyx (cabozantinib ...