Differential cytokine production was, in turn, underlain by disparate modalities of MyD88- versus TRIF-dependent signal transduction, resulting in mutually antagonistic pathways of canonical and ...

"These results revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice ...

6 "We used an siRNA approach to show that TRIF was involved in both the Toll3 and the Toll4 pathways while the fourth adapter, TRAM, was involved only in Toll4 and not Toll3 signaling," says ...

"These results revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice ...

"These results revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice ...

"We found that ablation of TRIF significantly shortens survival time of ALS mice," says Okiru Komine, first author of the study. "While MyD88 is also a crucial adaptor for most TLR signaling pathways, ...

TLR-4 is an important receptor in innate immunity, which signals activation via two pathways, TRIF and MyD88. The researchers found that lung injury was mediated exclusively through the TRIF pathway ...

New research has now identified an immune pathway affected by changes in iron ... and triggering an inflammatory response (the TLR4/TRAM/TRIF pathway). As drugs that mimic the altered iron ...

"These results revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice ...

Specifically, these mice have low levels of free iron in immune cells known as macrophages and this impairs signaling along a pathway required ... (the TLR4/TRAM/TRIF pathway).