The authors' work is supported by the German Cancer Aid (Deutsche Krebshilfe, #107854), the DFG (Deutsche Forschungsgemeinschaft FR1298/5–1) and the DOKTOR ROBERT PFLEGER-STIFTUNG Bamberg ...

The GLP-1 drug landscape is about to change. Starting Thursday, off-brand versions of semaglutide will no longer be permitted to be sold—creating a possible problem for the Americans who've come ...

“El Mayo” has made billions through his fentanyl smuggling operation, a vast network that has become a main feature of the Mexican drug landscape. Cartels produce and transport the ...

Drugs that are taken orally need to pass through the lining of the gastrointestinal (GI) to be taken up. Transporter proteins found on cells that line the GI tract help with this process ...

Alice Valder Curran outlines the steps manufacturers should take to better prepare for upcoming executive actions on drug ...

Example 1: Cross-species comparison of drug handling of PAH excretion in the kidney transporter model Para-aminohippurate (PAH), a derivative of hippuric acid, is used to measure renal plasma flow.

URAT1 is a transporter that regulates urate levels, controlling its reabsorption in the kidneys. Despite being a target for drugs used to treat gout, little was known about how URAT1 works or how ...

As shown in Figure 1, treatment with Rutherrin® significantly enhanced the retention of all tested chemotherapeutic drugs, presumably through the inhibition of the ABC transporter efflux pump ...

Tilson, 36, who asked in court for leniency. Tilson said he didn’t profit from the drugs he procured for John Joseph Eckard Sr., 62, of Altoona, who was sentenced in February to 7.5 to 20 years ...

"The public needs to understrand that the drug landscape has changed with the introduction of fentanyl and synthetics. Every dose is potentially a lethal dose," Brian Leardo with the DEA's Houston ...

Drugs are eliminated in the kidney by glomerular filtration and/or tubular secretion. Uptake transporters in the basolateral membrane and export transporters in the luminal membrane of renal ...