The authors' work is supported by the German Cancer Aid (Deutsche Krebshilfe, #107854), the DFG (Deutsche Forschungsgemeinschaft FR1298/5–1) and the DOKTOR ROBERT PFLEGER-STIFTUNG Bamberg ...

Drug Summary Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for glucose reabsorption in the kidney. It is used clinically as an ...

The GLP-1 drug landscape is about to change. Starting Thursday, off-brand versions of semaglutide will no longer be permitted to be sold—creating a possible problem for the Americans who've come ...

Drugs that are taken orally need to pass through the lining of the gastrointestinal (GI) to be taken up. Transporter proteins found on cells that line the GI tract help with this process ...

Example 1: Cross-species comparison of drug handling of PAH excretion in the kidney transporter model Para-aminohippurate (PAH), a derivative of hippuric acid, is used to measure renal plasma flow.

URAT1 is a transporter that regulates urate levels, controlling its reabsorption in the kidneys. Despite being a target for drugs used to treat gout, little was known about how URAT1 works or how ...

This successfully maintains transporter expression, replicating the mechanisms of drug excretion in renal proximal tubules in vitro, mimicking the function of human epithelial tissue. "Listening ...