The ability of thiazide-type diuretics to reduce BP seems to be linked to the presence of functioning renal tissue; thus, these drugs will not reduce BP in hemodialysis patients. [6] ...

21 It is conceivable that the thiazides could interfere with the action of bacterial enzymes ... Hemoconcentration induced by thiazide diuretics could also play a part in producing apparent ...

Of the questions concerning diuretic therapy: class effect, mechanism of action, and additivity with other medication classes are noteworthy issues. The manner in which thiazide-type diuretics ...