The ob gene -- ob for obesity -- was moved into mice in 1995, and the photo of the fat mouse next to the thin mouse with the ob gene was carried by nearly every media outlet in the nation. Overnight ...

Leptin, the product of the ob gene, is a hormone that regulates body weight by decreasing food intake and increasing energy expenditure. After binding to its receptor in the hypothalamus and other ...

Friedman's research team cloned the ob gene in 1994 and discovered leptin in 1995. Since then, much of Friedman's research has focused on understanding how leptin exerts its effects on body weight ...

But the discovery of the obese gene (ob gene) in 1994 by Jeffrey Friedman, a Howard Hughes Medical Institute investigator at Rockefeller University, has revolutionized the search for new therapies to ...