The discovery of the ob gene and leptin -- its protein -- triggered the hope that leptin would usher in a new therapeutic approach for some cases of obesity. Saladin R, De Vos P, Guerre-Millo M, et al ...

But the discovery of the obese gene (ob gene) in 1994 by Jeffrey Friedman, a Howard Hughes Medical Institute investigator at Rockefeller University, has revolutionized the search for new therapies to ...