Since the discovery in 1994 of the obesity gene and its product, the fat-busting protein leptin, scientists have been racing to understand and apply this modern marvel. The ob gene -- ob for obesity - ...

Friedman's research team cloned the ob gene in 1994 and discovered leptin in 1995. Since then, much of Friedman's research has focused on understanding how leptin exerts its effects on body weight ...

The product of the ob gene, leptin is a circulating hormone produced by white adipose tissue that has potent effects on feeding behavior, thermogenesis and neuroendocrine responses. Leptin ...

In the past, obesity often was considered a sign of weak willpower and a lack of self-restraint. But the discovery of the obese gene (ob gene) in 1994 by Jeffrey Friedman, a Howard Hughes Medical ...

"We were only able to find Foxa-2 in fat tissues when we extracted fat from a leptin-deficient mouse, which has a mutation in the 'ob' gene," says Stoffel, referring to studies with mice that are ...

identifying the protein responsible for obesity in genetically obese mice (six years before identification of the ob gene), and exploration of gut factors regulating metabolism, such as the ...

Leptin is a 16 kDa adipose-derived protein comprising 167 amino acids. The hormone is coded for by the ob gene which is located on chromosome 7 in humans. The majority of the leptin hormone is ...

She said her own doctor was unaware of the gene. “My OB-GYN was aware of my mom’s history and never suggested genetic testing,” Ms. Marsh said. “She never heard of it. I educated her.

One in every 500 women in the United States has a mutated BRCA gene which can lead to cancer. Knowing whether someone is a carrier can change prevention measures and treatment. Walther’s OBGYN ...