Monroe Wall, Mansukh Wani and colleagues at the Natural Products Laboratory of the Research Triangle Institute discovered and elucidated the structure Taxol ® and camptothecin, two life-saving ...

Taxol is one of the most successful cancer drugs ... researchers systematically manipulated the drug's chemical arms and legs to find a structure that might bind better to both normal and mutated ...

leads to a compaction of the E-site and a rearrangement of the α-tubulin monomer that generates a strain on the microtubule that destabilizes its structure. Taxol binding leads to a reversal of ...

This comparison clearly showed the effect Taxol has on microtubule structure. Other coauthors of the paper are former UC Berkeley biophysics graduate student Gregory M. Alushin, now of the ...

Next, the chemical structure must be elucidated (solved), which is done by use of a powerful arsenal of analytical instruments. This process can take years because natural products often have very ...

one of which is to act like a type of skeleton structure that helps give cells their shape. When cells replicate, they break down this skeleton, divide into two cells, then rebuild it. Taxol acts ...

Example: A strain named HQD33, with a considerable production yield of paclitaxel, has been isolated and screened from the bark of a hundred-year-old Taxus tree. Through various methods such as ...

Even though the isolation of paclitaxel (or "taxol") in pure form took several years, the chemical structure was finally published in 1971. Antitumor activity of paclitaxel was confirmed in 1977 ...