T cells are the immune system’s frontline fighters. When they detect danger, they rapidly multiply and transform into effector cells that destroy pathogens. This transformation demands an intense ...

He made a conceptual leap in immunotherapy by creating a hybrid T-cell, known as CAR-T, that was genetically modified to ...

CD19-directed CAR T-cell therapy led to persistent complete remission in 15 patients with three distinct autoantibody-dependent autoimmune diseases. News & Perspective Tools & Reference CME/CE More ...

Scientists have discovered that autoimmunity can be triggered in the thymus, where the immune system's T cells develop, if T cells fail to recognize just one of the body's thousands of proteins as ...

T cells represent a central component of the adaptive immune system, orchestrating responses that protect against pathogens while maintaining tolerance towards self-antigens. Their dysregulation ...

Despite a regulatory setback for Provention Bio’s diabetes prevention candidate teplizumab, hopes remain high for T cell-regulating therapies in autoimmune indications including multiple ...

Further study is needed to determine whether rogue killer T cells are involved in all autoimmune diseases, and what proportion of people with rheumatoid arthritis and other autoimmune conditions ...

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000;12:171-181. Crossref. PubMed. Web of Science. Google Scholar. 31.

Possible trigger for autoimmune diseases discovered : B cells teach T cells which targets must not be attacked. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2024 ...

Since this type of CAR T therapy uses cells that live for a limited amount of time, it won’t be a one-and-done infusion. Howard says longer and larger trials in the future will determine how ...

These Apex1-deficient cells couldn’t launch an autoimmune response. The results point to a new treatment strategy: targeting Apex1 might help suppress harmful immune activity in autoimmune diseases.

Autoimmune Disease Triggered If T Cells Miss A Single Protein Early On Date: November 22, 2006 Source: University of California - San Francisco Summary: ...