The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

Clathrin-mediated endocytosis (CME) plays a crucial role in synaptic vesicle trafficking, and it has been hypothesized that CME impairment contributes to neuropathology related to schizophrenia.

First discovered as proteins found on synaptic vesicles and at the presynaptic plasma membrane, SNAREs are members of a family of highly conserved proteins that reside on vesicles (v-SNAREs ...

Synaptic transmission is the biological process ... Genetically encoded dense core vesicle markers, compatible with immunohistochemistry and expansion microscopy, enable single-vesicle resolution ...

The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This ...

Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ... the presynaptic neuron and restored inside a vesicle ready to be used again.