How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are ...

Homeostatic plasticity, the brain's method of preserving equilibrium in neural circuits, relies heavily on spontaneous ...

VISUALIZING VESICLES:© 2003 Nature Publishing GroupIn A, researchers used a fluorescent protein (synaptopHluorin) to visualize synaptic vesicle movement. Some vesicles stay open briefly before ...

Reconstitution of synaptic vesicle formation in vitro has revealed a pathway of synaptic vesicle biogenesis from endosomes that requires the heterotetrameric adaptor complex AP3. Because synaptic ...

Imaging synaptic vesicles in 3D Date: December 3, 2024 Source: Max Delbrück Center for Molecular Medicine in the Helmholtz Association Summary: Researchers have used cryo-electron tomography to ...

Separation of presynaptic Ca v 2 and Ca v 1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca 2+ pump PMCA. Proceedings of the National Academy of Sciences ...

Reference: Gallimore AR, Hepburn I, Georgiev SV, O. Rizzoli S, De Schutter E. Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle. Sci Adv.

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

Synaptic vesicles are tiny, membrane-enclosed compartments that package and release messenger compounds, such as neurotransmitters, in neurons. Researchers have identified common proteins ...

This is important, he said, because true synaptic vesicles are packed full of other proteins (see May 2014 news story), making it hard to imagine where large α-synuclein multimers would fit in. Burré ...