HMG-CoA reductase inhibitors, commonly referred to as statins, are the cornerstone of pharmacologic reduction of elevated low-density lipoprotein cholesterol. LDL-C is the main contributor to ...

Clinical observations have suggested that statins — 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors — which are approved for reducing cholesterol, may also be beneficial in the ...

The CV benefit of statins can be partly explained by their ability to inhibit of HMG-CoA reductase, which subsequently lowers cholesterol and decreases the formation of mevalonate. However ...

Do not take two doses at the same time. Simvastatin and atorvastatin are cholesterol-lowering medications classified as HMG-CoA reductase inhibitors. They lower cholesterol levels by preventing ...

They work by inhibiting an enzyme in the liver called HMG-CoA reductase and ... that received the PCSK9 inhibitors actually had a significant reduction in their total cholesterol, and specifically ...

Statins belong to the prescription drug class called hydroxymethylglutaryl-coenzyme A (HMG CoA) reductase enzyme inhibitors. They work to reduce the production of cholesterol in the liver.

The ability of statins to inhibit HMG-CoA reductase is largely independent ... Rho and Rho kinase inhibitors (C3T and Y27632) increased ApoA1 production in HepG2 cells. Taken together, these ...

On the basis of these facts, I speculated that a cholesterol-synthesis inhibitor, particularly a HMG-CoA reductase inhibitor, would be an effective cholesterol-lowering agent. In the 1960s ...

What was the reason that the first discovered “statin” (HMG CoA reductase inhibitor) was never used in humans? The first statin discovered was mevastatin isolated from the fungus Penicillium ...