Another study set out to address a major limitation in spheroid biology, which is reproducibility. 4 “It’s well known that experiments performed in biology are hard to reproduce, whereas in other ...

Figure 2. Quantification of single spheroid invasion using Incucyte ® real-time analysis. U87-MG cells were seeded in a ULA round bottom 96-well plate (2,500 cells/well) and allowed to form ...

Three dimensional (3D) cell culture has been an area of increasing interest and relevance across a wide breadth of fields for some time now. One type of 3D structure generated in vitro are spheroids.

The use of 3D multi-spheroid live-cell assays formed on bio-matrices has been rapidly expanded in oncology research due to influence of tumor microenvironment.

Spheroid size. Spheroid size is determined by the cell type, seeding density, and culture time. As the spheroid becomes larger, it becomes more difficult for nutrients and oxygen to reach the ...

According to 3D Biomatrix, these models have great potential as drug-evaluation tools, especially early on in the process.

Monitoring of spheroid growth kinetics to determine growth delay and regrowth, respectively, after drug treatment requires long-term culturing (≥14 d).

Given that most spheroids are not perfectly spherical, size is best measured using a spheroid’s volume rather than its diameter. For volume determination, confocal and light sheet fluorescence ...

Gou Tanabe's graphic novel adaptation of H.P. Lovecraft's novella makes its monsters both terrifying and weirdly human. Even if space spheres aren't your thing, Tanabe's art still prompts wonder.

A spheroid is a three-dimensional cellular structure that has typically been used to culture cancer cells or embryonic stem cells for experimentation and research.