The combination of sitagliptin and metformin provided a more than additive effect on native GLP-1 concentrations. This combination may benefit patients with Type 2 diabetes through substantial ...

A total of 1,091 patients with type 2 diabetes and HbA 1c levels of 7.5–11.0% were randomly assigned to receive combination therapy with daily sitagliptin (100 mg) and metformin (either 1,000 mg ...

The study group consisted of stratum 1 (glimepiride alone, n = 212) and stratum 2 (glimepiride plus metformin, n = 229). Patients in each stratum were randomized to sitagliptin 100 mg once daily ...