Patients in each stratum were randomized to sitagliptin 100 mg once daily or placebo. Sitagliptin significantly decreased HbA 1c levels from baseline relative to placebo in the overall cohort as ...

A total of 1,091 patients with type 2 diabetes and HbA 1c levels of 7.5–11.0% were randomly assigned to receive combination therapy with daily sitagliptin (100 mg) and metformin (either 1,000 mg ...

Expert Rev Endocrinol Metab. 2008;3(6):691-697. Elimination of sitagliptin occurs primarily via renal excretion (79%) and involves active tubular secretion. Sitagliptin is a substrate for human ...