Activation of lung fibroblasts and differentiation to myofibroblasts are the principal effectors of disease pathology, but damage and senescence of alveolar epithelial cells, specifically type II ...

Breast cancer often relapses in distant organs even when complete regression of primary tumors is achieved after initial ...

Electrical signals could soon be used to quickly screen patients for diseases In a nutshell Japanese researchers developed a ...

A new research paper was published in Aging's Volume 16, Issue 13, entitled, “Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells.” ...

Fibroblasts produce the internal scaffolding that give skin tissues their structure. They pushed the fibroblasts towards senescence by damaging their DNA, which happens with aging.

Cell senescence was first identified by Leonard Hayflick and Paul Moorhead in 1961, when they serially passaged human fibroblast cells in culture. 3 They noticed that the cells stopped dividing after ...

A new research paper was published on the cover of Aging's Volume 16, Issue 4, entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.” ...

But when they undergo senescence, their destiny seems drab in comparison. They irreversibly exit the cell cycle, linger indefinitely, and die of undetermined causes. Senescent fibroblasts, in ...

Senescence was induced in normal colon fibroblasts isolated from colorectal rectal cancer patients resected from normal adjacent tissue. Senescence associated secretory phenotype (SASP) factors were ...

Senescence, a process long thought to be the “bad guy” behind aging, now shown to be essential in cardiac healing and regeneration. ... “the molecular mechanisms that control cardiac fibroblast ...

Certain therapies are being designed to trigger senescence in cancer cells, converting uncontrollably replicating cancer cells into dead-in-the-water zombie cells. While these therapies could stop ...