Breast cancer often relapses in distant organs even when complete regression of primary tumors is achieved after initial ...

Activation of lung fibroblasts and differentiation to myofibroblasts are the principal effectors of disease pathology, but damage and senescence of alveolar epithelial cells, specifically type II ...

Fibroblasts produce the internal scaffolding that give skin tissues their structure. They pushed the fibroblasts towards senescence by damaging their DNA, which happens with aging.

Electrical signals could soon be used to quickly screen patients for diseases In a nutshell Japanese researchers developed a ...

A new research paper was published on the cover of Aging's Volume 16, Issue 4, entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.” ...

Cell senescence was first identified by Leonard Hayflick and Paul Moorhead in 1961, when they serially passaged human fibroblast cells in culture. 3 They noticed that the cells stopped dividing after ...

Certain therapies are being designed to trigger senescence in cancer cells, converting uncontrollably replicating cancer cells into dead-in-the-water zombie cells. While these therapies could stop ...

But when they undergo senescence, their destiny seems drab in comparison. They irreversibly exit the cell cycle, linger indefinitely, and die of undetermined causes. Senescent fibroblasts, in ...

Senescence was induced in normal colon fibroblasts isolated from colorectal rectal cancer patients resected from normal adjacent tissue. Senescence associated secretory phenotype (SASP) factors were ...

Senescence, a process long thought to be the “bad guy” behind aging, now shown to be essential in cardiac healing and regeneration. ... “the molecular mechanisms that control cardiac fibroblast ...

The key to reversing cellular aging may lie in a protein responsible for toggling cells between a "young" and an "old" state.. This is the conclusion of researchers from the University of Osaka ...