Researchers at Osaka University conducted the study using primary human foreskin fibroblasts (HFF-1 cells), which were cultured and passaged repeatedly to induce replicative senescence.

The key to reversing cellular aging may lie in a protein responsible for toggling cells between a "young" and an "old" state. This is the conclusion of researchers from the University of Osaka, who ...

Exogenous expression of the ras oncogene triggers senescence in human fibroblasts. Staining with DAPI reveals the gradual appearance of senescence-associated heterochromatin foci, transcriptionally ...

The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal ...

"Suppressing AP2A1 in older cells reversed senescence [aging] and promoted ... The team cultivated human fibroblasts (specialized cells that maintain the structural integrity of tissues) and ...