In addition, p53 is a master sensor of damage that triggers ... and increased activity of FOXO, SIRT1 and KLOTHO) and anti-ageing interventions (anti-diabetics, CR and resveratrol) seem to share ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...