inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2/M arrest during cell cycle ...
Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs) that, among other activities, causes cell-cycle arrest ... RB during the G1 phase of the cell cycle.
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