The arrest occurs from within G1, excluding contributions ... molecules to centrosomes (p53) in response to centrosome protein depletion is consistent with a role for centrosomes in the cell ...

The p53 tumor suppressor gene is ... of genes engaged in promoting growth arrest or cell death in response to genotoxic stress. A possible role for p53-related modulation of neuronal viability ...

The p53 gene is extremely important in cell biology as its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the “tumor suppressor gene.” However ...

Any problems that arise during this replication process can lead to damaged DNA, which can in turn cause growth arrest or ... loss of p53 in cancer cells that lack the G1 checkpoint." ...

For example, MDM2 binds to TP53 mRNA, controlling the rate of translation, [24] and MDM2 regulates the levels of itself, MDM4 and p53. [23,25,26] The pivotal role of MDM2 and MDM4 in the control ...

Any problems that arise during this replication process can lead to damaged DNA, which can in turn cause growth arrest or ... loss of p53 in cancer cells that lack the G1 checkpoint." ...