Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs) that, among other activities, causes cell-cycle arrest ... RB during the G1 phase of the cell cycle.

For example, MDM2 binds to TP53 mRNA, controlling the rate of translation, [24] and MDM2 regulates the levels of itself, MDM4 and p53. [23,25,26] The pivotal role of MDM2 and MDM4 in the control ...

inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2/M arrest during cell cycle ...