Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors, especially when permanent gene transfer ...

Lentiviruses have the unique ability amongst retroviruses of being able to infect non-cycling ... pseudotyped with the envelope of the vesicular stomatitis virus (VSV), the vector can serve to ...

Ironically, the latest technique for producing transgenic cattle is based on a retroviral vector strategy reminiscent of that employed two decades ago to produce the first genetically engineered ...

The second was selected by CD34 +, stimulated with cytokines, transduced with MDR-1 retroviral vector and then cryopreserved; this served as the only source of cells for the second transplant.

This article examines viral and non-viral vectors in gene therapy, highlighting their mechanisms, advantages, and limitations ...

Vector production (clinical-grade plasmid DNA and retroviral vectors). Research and development work relating to vector production and transduction of patient cells. Molecular analysis of gene ...