During the past few years, the demand of receptor tyrosine kinase inhibitors is increasing exponentially as several studies have demonstrated a crucial role of these receptors in the regulation of ...

Our data suggest that EGFR tyrosine kinase mutations can be used to identify the subgroup of patients with non–small-cell lung cancer in whom this growth factor receptor may be essential to ...

Mesenchymal epithelial transition (MET) proto-oncogene receptor tyrosine kinase (RTK) is a cell surface receptor selective for hepatocyte growth factor (HGF), and is involved in embryogenesis ...

SU11248, a multitargeted receptor tyrosine kinase inhibitor of VEGF and PDGF receptors, demonstrates antitumor activity in metastatic RCC as second-line therapy, a setting where no effective systemic ...