A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) ...

Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative ...

New research identifies a promising strategy for correcting dopamine imbalances in the brain using a drug that blocks kappa ...

Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the University of ...

Dopamine, a small molecule derived from the amino acid tyrosine, plays a significant role in regulating multiple essential ...

Researchers have revealed the mechanism underlying GPCR function using a GPS nuclear magnetic resonance (NMR) technique.

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

A study from VIB-KU Leuven reveals how the interaction between the proteins GPR158 and PLCXD2 regulates synaptic maturation.

Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4. While the ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Feng-Jie Wu et al. Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes. Science , 2025 DOI: 10.1126/science.adq9106 Cite This Page : ...

Taste, pain, or response to stress — nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the ...