The most common doses of Seroquel used in clinical sleep trials ranged from 25 mg to 300 mg once daily before bed. Some clinical trials recommend a starting dosage range from 50 mg to 150 mg per day.

Quetiapine (as fumarate ... then titrate to effective dose, usual range: 150–300mg/day. Elderly, debilitated, or risk of postural hypotension: titrate more slowly to lower target dose.

Therefore, the convenient dosage regimen and rapid initiation scheme of quetiapine extended release (XR) were expected to provide better effectiveness and promote adherence in patients with ...