Moreover, our findings reveal that the pyrimidine compounds showed synergistic effects when combined with cisplatin and etoposide, suggesting their possible use in association with chemotherapy." ...

We report here the structures of p38α bound to compound 1 (a pyrimidine imidazole compound), to compound 3 (a quinazolinone) and to compound 4 (a pyridol-pyrimidine). The structure of p38α bound ...