Data also suggested increased formylated folate pool and increased purine synthesis when folate is adequate. The impacts of MTHFR 677T polymorphism appeared closely related to folate status ...

Pemetrexed, an folate analogue that inhibits multiple enzymes involved in purine and pyrimidine synthesis (thymidylate synthetase, dihydrofolate reductase, glycinamide ribonucleotide ...

They showed that the SARS-CoV-2 remodels the host folate and one-carbon metabolism at the post-transcriptional level to support de novo purine synthesis for the virus' genome, bypassing the viral ...

Guanine is also a component of important biomolecules such as GTP (guanosine triphosphate), which is involved in cellular signaling and protein synthesis. In addition to their role in nucleic acids, ...

A new study describes a core enzyme involved in the synthesis of these building blocks, called purines, and how the enzyme might change during infection by herpes simplex virus. Neuron-like cells ...

So far as is known today, uric acid serves no biochemical function in the body other than being an end product of purine metabolism. The metabolically important purines, adenine and guanine, serve ...

A team led by researchers from Penn State optimized a new method to create the synthetic neurons, which they used to investigate a core enzyme involved in the synthesis of purines — a component of DNA ...

A team led by researchers from Penn State optimized a new method to create the synthetic neurons, which they used to investigate a core enzyme involved in the synthesis of purines — a component of DNA ...