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allowing the prothrombinase complex to function with APC, and (3) inhibiting APC slowly. Clinical trials show low thrombotic risk, with no significant D-dimer elevations, indicating controlled ...
The tenase complex (FVIIIa:FIXa) amplifies the clotting cascade by activation of FX to FXa. The prothrombinase complex (FVa:FXa) activates prothrombin to thrombin, the central protease of the ...
This BsAb replicates the function of coagulation factor VIII by promoting the formation of the prothrombinase complex and subsequent clot formation. Vabysmo (faricimab, Roche) – Approved in 2022 ...
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