Viruses and bacteria are always trying to sneak into our bodies, but researchers at the University of Missouri are discovering that our own biology may already hold the keys to fighting off some of ...

Taste, pain, or response to stress — nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the ...

Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By ...

The GRAFS classification system of G-protein coupled receptors in comparative perspective. Gen Comp Endocrinol. 2005;142(1):94-101. Rosenbaum DM, et al. The structure and function of G-protein-coupled ...

G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an ...

Wikimedia Commons, Valeryns The 2012 Nobel Prize for Chemistry goes to Robert J. Lefkowitz of Duke University and Brian K. Kobilka of Stanford University for their work in discovering the inner ...

This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

Within cell membranes, ion channel receptors typically activate in response to electrical, chemical or other specific stimuli, explains Feng Qin, PhD, professor of physiology and biophysics and senior ...