Figure 2: Classical versus electron-based methods for fragmentation of protein and peptide ions in tandem mass spectrometry. Top-down mass spectrometry has made valuable contributions to our ...

“Top-down” is the term used to describe an alternative proteomics approach, where proteins are not enzymatically digested into peptides. They are introduced ... interrogate structures of large ...

Scientists say a new ‘top-down ... with protein inference, where protein isoforms generated from native processes such as alternative splicing generate a number of identical tryptic peptides.

The flexibility in their structure allows peptides to interact effectively with different receptors in the body, making them essential in signaling pathways. On the other hand, proteins are larger ...

Rather than try to map ... peptides that CLIP indicated could bind to the protein and showed that four could effectively bond to and degrade their target. By destroying the protein, they can slow ...

Collagen peptides are made by breaking animal collagen down through hydrolysis. So, while collagen is a complete protein, collagen peptides are fragments of that protein. Whole collagen is ...

"Understanding the structural diversity of nascent peptides formed in the ribosomal tunnel and their role in translational regulation can aid the elimination of bottlenecks in protein synthesis ...

Neurodegenerative diseases like Alzheimer's disease or Parkinson's disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure.