Codeine phosphate 10mg, promethazine HCl 6.25mg; per 5mL; syrup; contains alcohol 7%. Risk of life-threatening respiratory depression and death related to ultra-rapid metabolizers of codeine (esp.

After enrollment and completion of study period 1 (treatment D, 50 mg [10 mL] of promethazine oral syrup), one subject was withdrawn from the study because of violation of study protocol.

Putting on their detective hats, the NDEWS team discovered that increased saccharine in drugs was caused by users adding cough syrup to promethazine. The signal for this combination was detected ...

The recreational use of promethazine with codeine syrup is illegal because it contains codeine, an opioid, and can lead to addiction, respiratory depression, overdose, and even death when abused.

The pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories at three dosage strengths and oral syrup were studied. The study had an open-label, randomized ...