The authors concluded that the GGGGCC RNA and proline-arginine dipeptide work together in the same toxic pathway. Finally, Wen addressed the hypothesis that neurons need C9ORF72 to survive. She used ...

As a control, the authors made an interrupted poly(GA) gene, with a proline inserted after every fifth GA repeat ... Moreover, these aggregates included poly(GA), suggesting the repeat dipeptide ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction.