PREGNENOLONE (Δ 5-pregnen-3βol-20-one) has recently been recommended as effective in the treatment of rheumatoid arthritis. 1–5 Since Cortisone (17 hydroxy-11 dehydrocorticosterone) and ACTH ...

Pregnenolone is a steroid hormone that naturally exists in our bodies and is instrumental in creating other hormones including estrogen, testosterone, and cortisol. With advancing age, the levels ...

Pregnenolone and 21-acetoxypregnenolone do not, in our opinion, represent such a drug. Summary. Twenty patients suffering from rheumatoid arthritis and 1 patient with gout were treated.

Pregnenolone is a steroid hormone that plays a key role in the production of other steroid hormones, including progesterone, ...

In a new study, they present two enzymes from the CYP87A family as key enzymes that catalyze the formation of pregnenolone, the precursor for the biosynthesis of plant steroids, ...

Pregnenolone prevents THC, the main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that when overstimulated by THC causes the intoxicating effects of ...

Pregnenolone does not actually prevent THC or the brain’s own cannabinoids from reaching their receptors by physically blocking them— instead it changes the way the receptors react.

Pregnenolone is strongly upregulated by Δ9-tetrahydrocannabinol (THC) and limits several addictive and other effects of THC.