Total insulin ± S.E.M., representing the sum of the insulin concentrations at zero, a half, one and a half, two, three, four and five hours, is indicated by the vertical bars in the lower half of ...

Hormones like cortisol and insulin, which manage stress and blood sugar, are known to follow rhythmic release patterns, ...

Serum insulin concentration at 30 minutes after a 75-g dose of oral glucose was determined at baseline as a measure of insulin secretion. Outcomes were assessed at 6, 12, and 18 months.

Although fasting blood glucose concentrations did not differ between groups (nonobese 73 ± 2, and obese 74 ± 2 mg per 100 ml), there was a significant elevation in fasting immunoreactive insulin ...

We performed physiological studies of β-cell stimulus–secretion coupling in islets isolated from 7–9-week-old mutant mice and found reduced hyperpolarization of the mitochondrial membrane ...

Currently, T2DM is managed by a progressive stepwise introduction of lifestyle interventions, followed by the use of oral agents alone and in combination and, finally, insulin. While some evidence ...

LysoPI lipids show promise in boosting insulin secretion in diabetics. ... The role of lipids in the physiological and pathological processes of human metabolism is gradually becoming clearer, ...

Beyond the secretion of insulin, β cells also secrete functional exosomal miRNAs that contribute to an integrated glucose homeostasis loop, which largely extends our understanding of islet function.

Between 2016 and 2022, the researchers measured insulin secretion in response to carbohydrates (glucose), proteins (amino acids), and fats (fatty acids) from pancreatic islet cells taken from 140 ...

The research group led by professor Makoto Tominaga and Dr. Kunitoshi Uchida, National institute for Physiological Sciences (NIPS), Japan, found TRPM2 ion channel in pancreatic beta-cells is ...