Medscape11d
Pharmacokinetics of Promethazine Hydrochloride After Administration of Rectal Suppositories and Oral Syrup to Healthy Subjects
At intervals of five to nine days, healthy volunteers were given two 12.5-mg promethazine rectal suppositories, one 25-mg suppository ... request from the Food and Drug Administration.
Medscape1mon
Evidence-Based Approaches to Managing Nausea and Vomiting in Early Pregnancy
25 mg rectal suppository bid; maximum dose is 40 mg/day Sedation, anticholinergic effects, mouth, EPS, hypotension if given IV too quickly C Promethazine (Phenergan) 12.5–25 mg q 4–6 h PO/IM ...