While Smith and his colleagues’ peptide libraries demonstrated the potential of phage display, the sequences were randomly generated. Scientists did not have control over the amino acid frequencies, ...

Scientists insert variable DNA sequences coding for their proteins of interest into plasmids that carry a phage coat protein gene, an antibiotic resistance gene, and a packaging signal. Then they ...

They took a technique in which viruses are engineered to display bits of proteins like flags on their surface, called phage ...

Of the 23 fully human mAbs approved so far, 17 are derived from transgenic mice and 6 were developed with phage-display technology. Yeast display has generated a clinical pipeline, but no marketed ...

Bacteria navigate tradeoffs between phage resistance and interbacterial competition. This study reveals that while LPS ...

Because phages exert pressure on the bacteria they infect and some phage genomes encode virulence factors and toxins, a role for specific phages or communities of phages in human health seems ...

Their potential as antibacterial agents was appreciated almost immediately, with the first 'phage therapy' trials predating Fleming's discovery of penicillin by approximately a decade. In this ...