Figure 4: Structures of the substrates and transition states for peptide bond formation shown in similar orientations. The two-step mechanism identified here is markedly different from what has ...

Thus, the peptidyl transferase centre may use this induced-fit mechanism to help catalyse both essential reactions in which it participates: the peptidyl transferase reaction during elongation and ...

Peptide bond formation is one of the key chemical ... experiments that would explain their presence and formation mechanism. Such fundamental studies can then be applied in modern synthetic ...

A novel peptide appears to enhance a natural mechanism for protecting stressed ... an inactive state inside the cytoplasm. That natural bond sets Nrf2 up for degradation, likely preventing ...

This study provides a deep understanding of NET's transport mechanism, offering a crucial structural foundation for the development of novel peptide-based drugs targeting the MATs family.