Your body constantly builds new bone to replace the old. But with Paget's disease, this happens too fast and gives your bones an odd shape. They may be bent, weak, brittle, soft, or too big.

Paget’s disease is a rare disorder of the bone affecting the rate of formation and destruction of various bones of the skeleton. It is common in the elderly and those from European descent.

Paget’s disease of the bone is a rare condition that causes weak, misshapen bones. It’s chronic, meaning it’s a long-term disorder. However, when treated early, bone deformities and pain can ...

Age at onset of bone disease Distribution Bone symptoms Other clinical features Histology; Familial Paget's disease (also known as osteitis deformans) 602080: Autosomal dominant: 5q35 9p13 ...

In Paget’s disease, the balance between bone removal and bone building gets disrupted. Bone building begins to occur at a faster pace than bone removal. The resulting new bone is brittle, ...

Paget’s disease of the bone: This condition is diagnosed using X-rays, lab tests, and bone scans. A biopsy might be used to rule out other diseases.

Paget's disease-associated mutations in SQSTM1 appear to predispose patients to disease by potentiating NF-κB signaling, although additional mechanisms are possible. These mutations alone are ...

In Paget’s disease, the balance between bone removal and bone building gets disrupted. Bone building begins to occur at a faster pace than bone removal. The resulting new bone is brittle, ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking Paget's ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in ...