Cells of the innate immune system use germline-encoded receptors designed to recognize conserved molecular patterns and have been coined pattern recognition receptors (PRRs). The nature of the ...

which probably involves the formation of a multiprotein complex containing PRRs, is still unknown. We call the second cascade the 'danger signal extracellular pathway'. Both pathways are required ...

To test this, PhD student Daniela Flores-Gomez from the team of Niels Riksen and Siroon Bekkering at Radboud University Medical Center, Netherlands, isolated blood stem cells and white blood cells ...

However, research published today in Stem Cell Reports provides evidence that brief exposure to certain danger signals can prime the body's innate immune system into a long-term hyperreactive and ...