Keisuke Ito et al. uncover a new pathway regulating hematopoietic stem cell maintenance and function. In this pathway, the promyelocytic leukemia protein (PML) regulates the activity of the PPAR ...

"It binds to and activates the PPAR δ nuclear receptor. When you turn it on, it promotes cancer. It can stimulate cell proliferation and affect inflammatory pathways," DuBois said.

A Pathway To Blocking Autoimmunity Date: July 21, 2004 Source: ... the researchers profiled each gene regulated by PPAR-gamma to characterize the pathway leading to NKT activation.

Once they found that PPAR-gamma was expressed in dendritic cells, the researchers profiled each gene regulated by PPAR-gamma to characterize the pathway leading to NKT activation.

BB1 treatment activates the toll-like receptor (TLR)-2/TLR-6 signaling pathway, leading to the activation of peroxisome proliferator-activated receptor γ (PPAR- γ).

PPARs are categorized into three subtypes: PPARα, PPARβ/δ, and PPARγ. ... This mechanism has shown significant potential in targeting various cancer-related pathways, ...

A new study from MUSC Hollings Cancer Center researchers shows, for the first time, that a receptor called PPAR δ, or peroxisome proliferator-activated receptor delta, is an important player in a ...

A molecular pathway involving peroxisome-proliferator–activated receptor γ (PPAR-γ) and its downstream effector molecules — the transcription factors STAT5 and HIF-2α and the regulatory ...

InMed Pharmaceuticals (Nasdaq:INM) recently released preclinical data indicating its proprietary, small molecule compound, INM-901, targets multiple biological pathways associated with Alzheimer ...

The metabolic syndrome is by now unequivocally established in the minds of endocrinologists as a common and burgeoning disease linked to premature atherosclerosis and cardiovascular disease. Many ...

Working with isolated cells from mice and human cell lines from patients with the disease, Harmon identified that multiple genes affected by PPAR-γ were reduced in cystic fibrosis.