Connecting the outside-of-the-cell portion of PD-1 with the inside portion is the transmembrane segment. Many immune receptors function in pairs called dimers, but to date, PD-1 has been thought ...

Combination treatment could also benefit patients with lung, bowel, pancreatic and other solid cancers who don’t respond to ...

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

PD-1 deficiency enhances Treg cell pro-tumor function Lim et al. demonstrate that Treg cells deficient in PD-1 occupy key spatial niches within the TME, with regulatory subsets organized near tumor ...

In 1992, graduate student Yasumasa Ishida discovered PD-1, marking the beginning of a journey that would make this molecule a ...

Much of our understanding of PD-1’s functions, like many proteins, comes from studies in mice, based on the assumption that rodent and human biology operate similarly. However, human and mouse PD-1 ...

Stuart Tangye, Head, Immunology and Immunodeficiency Lab, Garvan Institute of Medical Research The researchers focused on the molecule PD-1, which acts as a 'handbrake' on the immune system ...

Hong Kong's Akeso has ended the week on a high note, with an FDA approval for its PD-1 inhibitor penpulimab and more data on PD-1/VEGF bispecific antibody ivonescimab. Penpulimab has picked up a ...