Blocking the MDM2–p53 interaction to reactivate wild-type p53 function is therefore a promising cancer therapeutic strategy, especially in this setting. At Boehringer Ingelheim, we have ...
The groups interested in studying p53 next wanted to investigate its interactions with T antigen. Scientists made these findings as the theory of oncogenes, the idea that mutated host growth-promoting ...
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When the number of chromosomes goes off track 🧬The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of ...
No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...
One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.
Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...
A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.
PNC-27 is a synthetic peptide composed of 32 amino acids. It is engineered to contain the MDM-2 binding domain of the tumor ...
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