New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

detecting errors in DNA and deciding how to handle them. If the damage is minor, p53 instructs the cell to repair it. But if the damage is beyond repair, p53 triggers a process called apoptosis ...

A first-ever analysis of the whole Greenland shark genome gives researchers a couple of clues to their longevity.

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of ...

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and ...

The CRISPR-Cas9 tool appeared to activate a DNA repair pathway governed by p53, a protein known as the “guardian of the genome.” 7 This was expected for an editing tool that deliberately generates ...

DNA damage and repair refers to the creation and correction ... show that this process is suppressed by p53 and that activation of p53 reverses some features of aging in vivo.

“Altogether, we’ve identified a cellular circuit capable of promoting DNA repair and genome integrity ... one day design a treatment that targets p53 to promote healthier aging.” ...