A large segment of the CYP2C19 rapid metabolizer subgroup is nonresponder to the PPI treatment, only partial symptom relief in GERD, more frequent unsuccessful eradication therapy and lower healing ...

Omeprazole is a popular medication used to treat conditions associated with the esophagus and stomach. It is classified as a proton pump inhibitor and can be purchased over the counter or with a ...

Omeprazole, the prototype drug of PPIs, is metabolized primarily by CYP2C19 to 5-hydroxyomeprazole. 5-hydroxyomeprazole is then transformed into 5-hydroxyomeprazole sulfone by CYP3A4. Omeprazole is ...