They should not take over-the-counter (OTC) medication for diarrhea without first talking with a doctor or pharmacist. In some cases, a person may need to come off baclofen for a short while.

Baclofen may be safe to take with acetaminophen (Tylenol). Acetaminophen is an over-the-counter (OTC) drug that is used to relieve minor aches and pains, such as headaches or muscle aches.